Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1

Abstract A tight synchrony between the DNA and centrosome cycle is essential for genomic integrity.Centriole disengagement, which licenses centrosomes for duplication, occurs normally during mitotic exit.We recently demonstrated that mild DNA replication stress typically seen in cancer cells causes premature centriole disengagement in untransformed

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Problematics Intellectual Property Rights of Music Industriallization Indonesia After The Easy Trying of Creating Work

In 2020, the Indonesian government, under President Joko Widodo, enacted job creation regulations aimed at stimulating the national economy.However, these regulations faced significant opposition due to concerns about their potential negative impact on Intellectual Property Rights (IPR).While the Copyright Act provides some protection for intellect

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